Creative Biolabs Lifescience Knowledge Center
Creative Biolabs Lifescience Knowledge Center that periodically updates news and industry event information.
20 Episodes
ADCP Assays
Antibody-dependent cellular phagocytosis (ADCP) is one crucial MOA of many antibody therapies. It is defined as a highly regulated process by which antibodies eliminate bound targets via connecting its Fc domain to specific receptors on phagocytic cells, and eliciting phagocytosis.
In Vivo ADME
Preclinical in vivo ADME study is an important component of the drug development process which is designed to investigate the absorption, distribution, metabolism, and excretion of test articles. In addition to supporting drug discovery, lead candidate selection, preclinical testing, and clinical programs, in vivo ADME study also plays a key…
ADCC Assays
There are plenty of sophisticated mechanisms in the human immune system to identify and eliminate unwanted cells (e.g., viral infection and tumor). Amongst these, antibody-dependent cellular cytotoxicity, namely ADCC, plays a crucial role.
6-OHDA Unilateral Lesion Rat Model of Parkinson's Disease
6-OHDA is a selective catecholaminergic neurotoxin that is used, mainly, to generate lesions in the nigrostriatal dopamine (DA) neurons in rats. This neurotoxin for PD model was first introduced in 1968 by Ungerstedt when he noticed that a unilateral application of 6-OHDA into the nucleus caudatus putamen or the substantia…
6-OHDA Unilateral Lesion Rat Model of Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder that affects about 1.5% of the global population over 65 years of age. Robust, well-validated pre-clinical models of PD are valuable tools for understanding the biology and possible treatment of this complex disease.
Collagen-Induced Arthritis (CIA) Rodent Model
Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Of the various animal models of…
Cecum Ligation and Puncture (CLP)-Induced Sepsis Model
Rodent disease models are widely used for a broad range of project objectives, which involve investigation of pathological process and mechanism of disease, pre-clinical tests of potential therapeutic agents, etc. https://www.creative-biolabs.com/drug-discovery/therapeutics/cecum-ligation-and-puncture-clp-induced-sepsis-model.htm
Pharmacokinetics Models
Pharmacokinetics (PK) models are generated to elucidate the transformations that a drug undergoes in an organism and the rules that determine this fate.
Rodent Behavioral Tests for Motor Function
Insults to the central nervous system can lead to severe motor impairments in gait or fine motor skills. To develop therapies for motor dysfunction, animal models which have a disease pathophysiology comparable to the clinical population are used. Smaller animals such as rodents are preferred by scientists due to various…
Pharmacology and Pharmacodynamics Studies
Pharmacology and pharmacodynamics studies are of great importance in determining a drug's effect during drug discovery and development. A large variety of animal models has been developed to provide investigators with the ability to characterize the pharmacokinetics and pharmacodynamics of therapy.https://www.creative-biolabs.com/drug-discovery/therapeutics/pk-pd-modeling.htm
Toxicity and Safety Evaluation
Prior to clinical trials, it is necessary to conduct animal toxicity studies to best characterize the potential toxicity of new drug candidates. Generally, the objective of preclinical safety evaluation is to determine the toxic effects with respect to target organs, dose dependency, the relationship between clinical findings and exposure to…
Process and Scale-up
In general, the work done in a laboratory cannot be simply multiplied up to an industrial scale because of the inevitable consequences of increased scale, such as a decrease in surface area and volume ratio. This may seem insignificant in the lab (for example a bit of foam), but it…
Pre-formulation Development
Formulation studies aim to develop a drug preparation which is both stable, safety and acceptable to the patient. Pre-formulation studies are an essential component of drug development process, and it provides the scientific basis for formulation development. It gives the physical, chemical, and mechanical properties of a new drug and…
Formulation Development
statistically designed experiment to understand formulation parameters that impact the safety, efficiency, manufacturability, and stability in primary packaging https://www.creative-biolabs.com/drug-discovery/therapeutics/formulation-development.htm
Drug Abuse Liability
Drug abuse liability is the potential that a drug has properties that facilitate people becoming addicted or dependent on it. This phenomenon may be caused by drugs' pharmacological and psychopharmacological properties or social aspects around their self-administration. The addictive potency of drugs varies between different drugs. For instance, drugs such…
Target Localization
Custom high-quality drug target localization services for functional analysis in the process of drug discovery https://www.creative-biolabs.com/drug-discovery/therapeutics/target-localization.htm
Metabolic Pathway Analysis for Fungi
Custom metabolic pathway analysis services for target identification and validation. https://www.creative-biolabs.com/drug-discovery/therapeutics/metabolic-pathway-analysis-for-fungi.htm
Radioautography
Custom digital imaging services using radioautography for functional analysis of drug discovery. https://www.creative-biolabs.com/drug-discovery/therapeutics/radioautography.htm
Atomic Force Microscopy
Custom digital imaging services using atomic force microscopy. https://www.creative-biolabs.com/drug-discovery/therapeutics/atomic-force-microscopy.htm
Confocal Laser Scanning Microscopy
Custom digital imaging services using confocal laser scanning microscopy with the advanced drug discovery platform. https://www.creative-biolabs.com/drug-discovery/therapeutics/confocal-laser-scanning-microscopy.htm