Collagen-Induced Arthritis (CIA) Rodent Model

Rheumatoid arthritis (RA) is a typical, chronic autoimmune disease that primarily affects the joints, ultimately leading to synovitis that often develops into cartilage and bone erosion, apart from which, extra-articular features are presented, including subcutaneous nodules, vasculitis, and pulmonary fibrosis, particularly in severer cases. Of the various animal models of rheumatoid arthritis (RA), collagen induced arthritis (CIA) is the most widely studied and used standard model, largely on the basis of the preclinical, pathological and immunological similarities between CIA and RA. Creative Biolabs offers CIA models elicited in genetically susceptible strains of both rats and mice by immunization with heterologous (usually bovine, chick, or rat) or autologous type II collagen emulsified in the adjuvant, resulting in different forms of arthritis (acute or protracted).https://www.creative-biolabs.com/drug-discovery/therapeutics/collagen-induced-arthritis-cia-rodent-model.htm